Lower, Mark A (1860) Patronymica Britannica: a dictionary of the family names of the United Kingdom. London: J.R. Smith. Public Domain.
SPAIN
As described in historical dictionaries
Patronymica Britannica (1860)
SPAIN. SPAYNE. May have had several distinct origins, from as many early settlers. The Essex family of Hispaine, or Spayne, were descendants of Alured Hispanieusis, or De Ispania, wdio at the Domesday survey was a tenant in chief in various counties. Morant's Essex, ii., p. 363.
Surname type: Location or geographical feature
Origin: English
Region of origin: British Isles
Country of origin: England
Religion of origin: Christian
Language of origin: English